Preparation, Characterization and Evaluation of Prasugrel Hydrochloride Nanosuspensions: Its enhancement of dissolution rate and oral bioavailability

The objective of this study was to investigate nanosuspensions for enhancing the solubility and dissolution rate Prasugrel HCl (PHCl) so as reduce fluctuations in its oral bioavailability. Hydrochloride were prepared using evaporative precipitation method. After preparation, various characterized particle size, scanning electron microscope (SEM), zeta potential, drug entrapment efficiency (EE), Fourier transform infrared spectroscopy (FTIR), differential calorimetry (DSC). Solubility in-vitro release from nanoparticles are determined. formulations techniques such powder x-ray diffractometry, microscopy, in-vivo absorption rats. form significantly higher than that suspension pure drug. All investigated can be used enhance prasugrel hydrochloride thus Nanosuspensions demonstrated better superior technique when compared other bioavailability Hydrochloride. nanosuspension successfully developed is 4 folds increased